Gastrointestinal adverse effects of GLP-1 agonistsincluding nausea, vomiting, and dehydrationcould be exacerbated by alcohol use and may complicate medication adherence
GIP receptor activation enhances adipocyte insulin sensitivity, promotes fat mobilization, and complements GLP-1s appetite and insulin effects through synergistic receptor cross-talk
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This is particularly true for patients who were started on insulin early in their disease course when their beta cells still had significant function, gained weight on insulin therapy, have A1C levels that might respond to GLP-1-mediated insulin secretion, or want the cardiovascular and weight loss benefits that GLP-1 medications offer
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Inulin is a fructan, a type of fermentable fiber that gut bacteria love to eat