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Pettinato, M
Although CGRP efficacy was not directly tested in tinnitus patients, the frequent co-occurrence of tinnitus and migraine and high levels of CGRP in both conditions have led to studies proposing that migraine treatments, especially CGRP monoclonal antibodies, may be effective in treating migraine-associated tinnitus
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Unfortunately, this compensatory surge is futile because the downstream clearance pathwaysspecifically the enzymes mitochondrial superoxide dismutase (SOD2) and glutathione peroxidase 4 (GPX4)are severely dysfunctional
However, before using, please consider any contraindications, including individual intolerance to any of the ingredients, pregnancy, lactation, and childhood
PMID: 11146367
