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Apart from the PPP, two subtypes of isocitrate dehydrogenase (IDH) isoenzymes can also generate NADPH based on their intracellular localization: mitochondrial NADP + -dependent IDH ( Idh2 ), as well as cytosolic and peroxisomal NADP + -dependent ICDH ( Idh1 )
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The mechanism underlying carnitine's anti-aging effects involves multiple pathways: restoration of mitochondrial cardiolipin content and membrane integrity, enhancement of fatty acid oxidation to reduce lipotoxic stress, reduction of protein oxidation and carbonyl formation, improvement of calcium homeostasis and cellular signaling, and activation of stress resistance pathways that promote cellular resilience
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Many other benefits include improving athletic performance and heart health
If left untreated, this can cause health problems, such as vision loss, heart disease, and kidney failure
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