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Cardiovascular diseases (CVDs) are a leading cause of death worldwide, driven largely by conditions like coronary artery occlusion, hypertension, and strokes

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Heart failure (HF) is currently considered a systemic multi-organ syndrome fundamentally driven by metabolic failure, and carnitines, a crucial metabolite in fatty acid metabolism, transport long-chain fatty acids into myocardial mitochondria to produce energy as a source of ATP generation [1] (Fig

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10.1016/j.molmet.2023.101807 91 MuellerN