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Acronyms A1C - Hemoglobin A1C ADA - American Diabetes Association CVD - Cardiovascular disease DM - Diabetes mellitus FBS - Fasting blood sugar GFR - Glomerular filtration rate GI - Gastrointestinal GIP - Glucose-dependent insulinotropic polypeptide GLP-1 - Glucagon-like peptide-1 HFpEF - Heart failure with preserved ejection fraction MASH - Metabolic dysfunctionassociated steatohepatitis NASH - Nonalcoholic steatohepatitis OSA - Obstructive sleep apnea RCT - Randomized controlled trial T2DM - Type 2 diabetes mellitus Thyroid C-cell tumor = Thyroid medullary tumor DRUGS IN CLASS Dual GLP-1 and GIP agonists Tirzepatide (Zepbound) - marketed for weight loss Tirzepatide (Mounjaro) - marketed for diabetes MECHANISM OF ACTION GLP-1 and GIP Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are hormones secreted by intestinal cells in response to eating
A person starts their GLP-1 medication, experiences constipation within the first week, panics, and immediately begins taking full doses of a fiber supplement
Semaglutide in Canada Health Canada has approved semaglutide for both diabetes management (Ozempic) and chronic weight management (Wegovy)
GLP-1 receptors, unlike opioid or dopamine receptors, do not appear to significantly downregulate with continuous stimulation
doi: 10.1155/2012/879151 24 SunWDongHWolfrumC
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