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Lin HM, Lee JH, Yadav H, Kamaraju AK, Liu E, Zhigang D, Vieira A, Kim SJ, Collins H, Matschinsky F, Harlan DM, Roberts AB, Rane SG

Methods Leveraging the target trial emulation framework, we conducted a retrospective study using observational data to emulate a new user, active comparator trial examining the effects of initiating GLP-1RA (exposure group) versus SGLT2 inhibitors (control group), with random treatment assignment emulated by propensity score matching with 1:1 ratio

This may aid weight loss, as impaired insulin sensitivity is likely tied to a higher risk of weight gain and obesity ( Still, more research is needed to evaluate the relationship between glutamine and insulin sensitivity

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Lara Boudreaux, MD