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Together, current evidence indicates that addictive drugs induce stimulus- and region-specific dopaminylation of histone H3, shaping transcriptional programs involved in reward processing and drug-seeking behavior

Furthermore, these toxic lipid products can react with nucleophilic amino acid residues within various proteins, forming covalent adducts and inducing protein lipoxidation [107]

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Supplemental folic acid use at the higher end of this suggested range has been recommended by some in order to ensure a minimum RBC folate concentration of 906 nmol/L (32) after four weeks of supplementation (30, 33), which would maximize NTD risk reduction particularly for those with low folate status

Agents 56 , 106118 (2020)