Oral amycretin showed up to 10.1% weight loss Evidence level: Low-moderate -- early-phase data with Lancet publication, impressive trajectories, but small samples and short duration
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In contrast, drugs such as Wegovy and Zepbound have shown an ability to produce weight loss almost to a similar extent as bariatric surgery
This cardiovascular outcomes trial of semaglutide versus placebo in patients with type 2 diabetes at high cardiovascular risk revealed an unexpected finding: patients receiving semaglutide experienced a statistically significant increase in diabetic retinopathy complications (hazard ratio 1.76, 95% CI 1.112.78, p=0.02)
Bjerre Knudsen L, Madsen LW, Andersen S, Almholt K, de Boer AS, Drucker DJ, et al
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