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Applying HbA1c thresholds of 7.5% (58 mmol/mol) and 8.0% (64 mmol/mol) for treatment intensification with the addition of basal insulin also did not change the conclusions of the analysis

GLP-1 therapies have long been recognized for their ability to regulate appetite, improve insulin sensitivity, and support weight loss by mimicking the natural hormonal signaling that occurs after food intake

Wegovy and Rybelsus both mimic GLP-1, which is why they belong to a group of medications called GLP-1 receptor agonists

Importantly, SELENOP expression was maximal in adjacent astrocytes, rather than the ependymal cells directly lining the ventricles

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Things To Know Mounjaro uses dual hormone technology targeting GIP and GLP-1 receptors simultaneously Trulicity focuses solely on the GLP-1 pathway for blood sugar control Both medications require once-weekly injections administered subcutaneously Mounjaro typically produces greater A1C reductions averaging 2.0% to 2.3% Trulicity has a longer track record with over 10 years of real-world use Weight loss tends to be more significant with Mounjaro due to its dual action Side effects for both primarily involve gastrointestinal symptoms Mounjaro is available in higher maximum doses than Trulicity How Mounjaro and Trulicity Work Differently The fundamental difference in how these medications function explains much of their varying results