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Greenspan, Case Western Reserve University, Cleveland, Ohio

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A key concept for understanding this interface is the model of allostasis (adaptation) and allostatic load (pathophysiology) [6] that we review below examining this model in relation to new insights from the recent work on the link between mitochondrial metabolism and epigenetic function to promote healthy behaviors and cognitive function

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The most common side effects were gastrointestinal, mostly mild to moderate, and tended to improve after initial dose escalation

Colburn WA, Gibson DM, Wiens RE, Hanigan JJ