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the clearest signal from trials and regulators points to gastrointestinal side effects like nausea and diarrhoea, which follow from GLP-1 action on the gut

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You should not change your dosing regimen or stop taking tirzepatide as prescribed without first discussing with your healthcare provider

Suggested Usage Two sprays in mouth once or twice per day or as recommended by a healthcare professional

The baseline assessment included a detailed sociodemographic data, medical history, frailty status assessment, physical function, cognitive function, nutritional status, and selected frailty biomarkers