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Phase-II Drug Metabolism Most of the time gives metabolite that is: More polar Non-toxic Pharmacologically inactive X = O, N, S Phenol, alcohol and carboxylic acid Amine (aliphatic and aromatic) Thiol Sometimes: Phase-II gives: Less polar conjugate: Methylated drug Acetylated drug Toxic metabolite: Some sulfate conjugates Some Acetylated metabolites

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The median follow-up period was 5.8 years (IQR, 4.4-7.6)