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Tsoli M, Chronaiou A, Kehagias I, Kalfarentzos F, Alexandrides TK

The ATTAIN-1 trial reported a mean change in body weight at 72 weeks of -11.2% with the highest dose of orforglipron 36 mg compared to -2.1% with placebo in adults with obesity or overweight and at least one weight-related comorbidity

Weight Management Support : May assist patients in reducing caloric intake over time through effects on appetite and digestion

TGF-1 promotes FLS migration and invasion by inducing epithelial-mesenchymal transition (EMT) via activating Smad-2/3 in RA (92)

For everyday use, apply 2-3 drops on a cleansed face and neck, then follow with moisturizer or brightening cream

However, they are not miracle drugs