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The medication works by mimicking a hormone that regulates hunger, making you feel fuller for longer and reducing cravings

This mechanismknown as delayed gastric emptyingis responsible for reduced hunger but also for initial nausea, constipation, or mild acid reflux that some patients experience during dose escalation phases

As a result of the success of GLP-1s, plan sponsors that cover weight-loss medications have seen a dramatic increase in spending on those drugs in the recent years

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This "dose-escalation" design facilitates the body's gradual adaptation to the medication, thereby reducing the incidence of common adverse effects such as nausea and vomiting

The secondary endpoint included changes in glucose, insulin, HOMA-IR, blood pressure, lipid profiles, uric acid, free fatty acids, hepatic profile, and the sensation of fatigue and hunger