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Name: tirzepatide blood brain barrier shows neuroprotective effects via regulating glucose metabolism in APP/PS1 mice tirzepatide blood brain barrier Increasing
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7.520 mg nasally)

Elife 8 , e45572 (2019)

As an alternative approach to improve in vivo stability of the fusion molecule, we then engineered a disulphide bridge into the exendin-4 peptide moiety (Ab#2_DSB#1) as this has been shown to improve in vitro and in vivo stability of both GLP-1 and exendin-4 analogue peptides 36