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The minimum effective drug holiday appears to be four weeks, with six weeks providing a more complete reset based on pharmacokinetic clearance data

Abruptly stopping the medication often leads to weight regain, so a planned approach is preferable

QT Prolongation Can cause heart rhythm abnormalities , especially in patients with underlying conditions or those taking other QT-prolonging drugs

Hamal S et al

Using Nooms meal logging feature can help, and its worth paying attention to sleep too, since poor sleep is linked to weight challenges

Avoid High-Fat and Greasy Foods Heavy meals may remain in the stomach longer while taking semaglutide, making nausea, bloating, indigestion, and reflux worse for some patients