Aggregated alpha-synuclein triggers the NLRP3 inflammasome by activating NF-B, which in turn triggers the cleavage of IL-1 and IL-18
ROS are generated as byproducts after electron leaking at complex I and III (Hernndez et al., 1993
Critically, a study has shown that the levels of GSH, a key antioxidant, are significantly reduced in the AD brain and that the extent of this depletion correlates positively with the severity of cognitive impairment (43)
Studies have shown that GHK-Cu can upregulate genes involved in collagen production and downregulate those linked to inflammation and oxidative stress [3]
Adems, como decamos, evita el deterioro cognitivo y previene el desarrollo de la enfermedad de Alzheimer, lo que ayuda a vivir ms aos con mejor salud
But as noted above, those studies had significant design limitations that undermine their conclusions