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If the DNA damage is too severe or there is a defect in the DNA repair pathway, DNA repair will ultimately fail 5-7

10.1016/j.cyto.2020.155050 31

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Seleninic or selenol intermediates generated from the oxidation/reduction of DSePA can follow the analogous catalytic steps as discussed for the native GPx enzyme in the earlier section to detoxify the hyperoxides by consuming the thiols [82, 83]

Smad, mouse signal transduction molecule

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