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(Also their social media people are killing the game, def recommend a follow)
497: 2507 Shihabi ZK, Oles KS, McCormic CP, et al
Done AJ, Traustadttir T
Benefits: Supports overall health
Taken together, the figure highlights a key mechanistic principle underlying the therapeutic rationale for multi-agonist strategies: while GLP-1R monotherapy achieves meaningful metabolic and hepatic benefits exclusively through indirect, systemic pathways, the addition of GIPR and - most importantly - GCGR co-agonism introduces complementary and increasingly direct hepatic mechanisms, providing the pharmacological basis for the superior efficacy observed with dual and triple agonists in MASLD/MASH
Jun 6 2012;15(6):838-847
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