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They are all small molecules which act as reversible competitive inhibitors of the catalytic activity of DPP-4 and, when used at the appropriate therapeutic dose, are associated with at least 70% inhibition of plasma DPP-4 activity (35) (although the actual extent of inhibition in vivo is likely to be higher, due to dilution of the inhibitor in the ex vivo assay)

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WARNINGS: If pregnant or breastfeeding, consult your healthcare practitioner before use

This modification stabilizes the molecule against dipeptidyl peptidase IV degradation while preserving full GHRH receptor activity

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