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To characterize the nature of changes in lipid composition by genotype and/or by EtOH treatment, hepatic neutral lipids (including cholesterol ester (CE) and triglyceride (TG)) were quantitated and profiled

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In the liver, feeding-induced FXR activation elevates SHP expression, which forms a complex with CREB to recruit lysine-specific demethylase 1 (LSD1) to the promoters of ATGs such as Tfeb, Ulk1 , and Atg7

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