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Control groups of mice were maintained on LD or WD and given sham (10 mL/kg body weight sterile saline) injections throughout the study (termed LD/LD-V, or LD control, and WD/WD-V, or WD control, groups

Dosing: Tirzepatide's therapeutic doses (515 mg/week) are significantly higher by mass than semaglutide (0.252.4 mg/week), requiring more active ingredient per vial

Look carefully, especially near the bottom of the vial and around the rubber stopper

Wang Q, Zhou C, Zheng Y, Pang H, Li S, Hu Y, et al

Excessive calorie restriction, inadequate protein intake, or improper dosing can worsen fatigue, slow metabolism, and intensify thyroid-related symptoms

On top of that, weight recurrence is really common in most patients "even those who enjoyed tremendous success on these medications," once the medication is stopped, Maselli said