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The incidence of markedly low serum potassium (less than 3 mEq/L, and a reduction from pretreatment of greater than 0.5 mEq/L) at any time during the trial was 0.2% for phentermine and topiramate extended-release 7.5 mg/46 mg dose and 0.7% for phentermine and topiramate extended-release 15 mg/92 mg dose, compared to 0% for placebo
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[2] Spironolactone is similar in structure to steroid compounds and can produce some of the same adverse effects
In fact, many benefits like improved metabolism, blood sugar balance, and reduced inflammation only become more pronounced with sustained usage