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GSH is the primary intracellular antioxidant and one of the key regulatory factors in GPX4 expression 30,31 .Through restoration of SLC7A11 expression, OSR facilitated greater cystine uptake and GSH accumulation, while simultaneously lowering the levels of lipid peroxidation by-products such as MDA and 4-HNE

In the polyol pathway, excess glucose is metabolized by aldose reductase into sorbitol, depleting NADPH and reducing glutathione levels, a critical antioxidant

Anderson ME et al

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