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As a result, a new ferroptosis inhibition axis with GTP cyclohydrolase-1 (GCH1) as the core was finally determined, which was found to be mainly regulated by the GCH1/BH4/DHFR pathway, which also protected cells from ferroptosis in a GPX4-independent manner (49, 50) ( Figure 1D )

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Key takeaways L-carnitine helps the body convert fat into energy, but research shows its weight loss effects are small and depend on factors like diet, activity level, and baseline carnitine levels

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