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Abstract Background Initiation of Glucagon-Like Peptide-1 receptor agonists (GLP-1RA) in patients with type 2 diabetes (T2D) treated with levothyroxine may decrease the required levothyroxine dose due to weight loss or enhance levothyroxine absorption through delayed gastric emptying

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Timing patterns from pooled data The STEP trials pooled data reveals several important timing patterns: The incidence of new-onset nausea was highest during the dose escalation period (weeks 1 to 20) and decreased substantially once participants reached maintenance dosing

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