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Gastroenterology 167 , 14571459 (2024)

GLP-1RAs excel at inducing short-term weight loss by imposing a powerful external satiety signal, whereas postbiotics may contribute to stabilizing the endogenous signaling environment that governs appetite regulation and metabolic adaptation ( Adipose tissue plasticity and thermogenic capacity: BAT, browning, and the physiological ceiling in humans The discovery of metabolically active BAT in adult humans raised expectations that obesity therapies might meaningfully increase energy expenditure through thermogenesis ( In humans, however, BAT mass is limited, heterogeneous, and reduced in obesity, and even maximal activation contributes only modestly to total energy expenditure ( Importantly, the physiological ceiling on BAT-mediated thermogenesis implies that increasing energy expenditure is unlikely to offset the metabolic adaptation associated with rapid weight loss

Garrido J, Borges F

If nausea lasts more than a day or gets worse, its a good idea to check with a healthcare provider

For a drug to be approved for the pregnant population, it must go through rigorous testing with that population, and that has not yet happened for semaglutide or other GLP-1 (glucagon-like peptide 1) agonists, says Carrie Burns , MD, a board-certified endocrinologist and director of diabetes in pregnancy at Penn Medicine in Philadelphia

However, the decision to switch should be based on a thorough discussion with your healthcare provider to weigh the potential benefits and risks