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Firefighters are exposed to toxic smoke, chemicals, and environmental pollutants, which can lead to respiratory damage, oxidative stress, and long-term health risks

2.1 Renal Impairment Study 2.1.1 Study Population Male and female participants of non-childbearing potential were eligible for inclusion in the renal impairment study if they were aged between 18 and 80 years with a body mass index (BMI) between 20 and 39.9 kg/m 2 and a body weight 60 kg at screening

Mu C, Corley MJ, Lee RWY, Wong M, Pang A, Arakaki G, et al

Kavouras et al., 2007)

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Science (New York, NY) 352:aaf1098