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Pharmaceutics 13 , 1042 (2021)

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Although several other medications have been linked to DIC, antibiotics remain the leading cause of this condition [60], along with underlying liver disease: for instance, in patients with a history of ICP, there appears to be a greater predisposition toward a cholestatic liver injury from oral contraceptives or postmenopausal hormone replacement, while rifampicin seems to be associated with an increased risk for hepatotoxicity in patients with primary biliary cholangitis (PBC) [64]