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However, the efficiency of GSH redox system declines with age, predisposing the RPE to increased oxidative-stress-mediated damage 15,16

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M., Melo van Lent, D., Tielemans, M

In addition, cross-breeding ALS-transgenic mice with ARE-human placental alkaline phosphatase (hPAP) reporter mice allowed to reveal that Nrf2 activity was more intense in skeletal muscle than in the spinal cord, and evident since before motor symptom onset [264]