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Recommended dose: Standard 1,0002,000 mg daily EPA+DHA combined (avoid very high doses unless GP-supervised)

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While statins remain first-line therapy for most patients according to ADA and ACC/AHA guidelines, some individuals may be taking niacin for specific indications such as severe hypertriglyceridemia or statin intolerance

Yamazaki N, Matsuo T, Kurata M, Suzuki M, Fujiwaki T, Yamaguchi S, Terada H, Shinohara Y: Substitutions of three amino acids in human heart/muscle type carnitine palmitoyltransferase I caused by single nucleotide polymorphisms