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Specific CYP3A4 inhibitors like troleandomycin have been shown to inhibit AFBO production [29], while inducers of CYP3A4 activity such as 3-methylcholanthrene and rifampicin, increase AFB 1 metabolism in cultured human hepatocytes [49]

It is important to consult with your veterinarian before supplementing your dog, as some over-the-counter supplements may not be appropriate and can contain dangerous ingredients, such as xylitol which is poisonous for dogs

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May warrant further evaluation with stimulation testing and consideration of either Sermorelin or synthetic HGH therapy