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Many people start with a low introductory dose and increase over several weeks to improve tolerability

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Most people start at 2.5 mg for 4 weeks, then increase to 5 mg, then 7.5 mg, then 10 mg, with potential further increases to 12.5 mg and 15 mg

The article also says many patients need their antihypertensive doses reduced over the first 12 weeks and that a provider may lower them proactively, which it frames as a clinician's decision made from your readings rather than something to act on alone