Practices vary globally, including how and when to give B12 shots
What it is / mechanism 5-Amino-1MQ is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide (consuming the methyl donor SAM) to form 1-methylnicotinamide, diverting nicotinamide away from the NAD+ salvage pathway
This is a genuine, published mechanistic pathway, but it has only been demonstrated in cell and mouse models, not in humans
A deficiency can cause skin discoloration, changes in hair texture, and nail issues
To maintain its effectiveness, B12 needs to be kept in a cool, dry place, far away from direct sunlight