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The ongoing TRIUMPH OUTCOMES trial will be key in determining the long-term cardio-renal effects of retatrutide in these populations

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in the Journal of Pharmacology and Experimental Therapeutics (which established Dihexas HGF/c-Met mechanism via Morris water maze rescue with HGF antagonist blockade) was the subject of an Expression of Concern in 2021 and was formally retracted in April 2025 by the publishing journal following investigation into image manipulation

Retatrutide will likely follow a similar pattern in those markets once approved there

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