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Short-term use is rarely effective because the underlying physiological drivers of obesitysuch as hormonal imbalances in appetite regulationoften return once the medication is stopped

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Since obesity is associated with an increased risk of cardiovascular disease, the ongoing SELECT study is investigating whether once-weekly semaglutide 2.4 mg will reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease [61]

The key research boundary is simple

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