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Curr Diabetes Rev 19:3145 Gejl M, Gjedde A, Egefjord L et al (2016) In Alzheimers disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: randomized, placebo-controlled, double-blind clinical trial

Both the nasal mucosa and lungs have large and highly vascularized surface areas for peptide absorption

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Research from pharmaceutical stability studies confirms this mechanism

1,2 Although the clinical trials of amitriptyline are old and involved small numbers of patients, a systematic review revealed that amitriptyline tended to show superiority over duloxetine, pregabalin, and milnacipran