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(2022) 12:e059834

Guo Y, Chen M, Liao M, Su S, Sun W, Gan Z

During the early stages of inflammation, melatonin functions transiently as a proinflammatory agent for 23 hours, which is necessary for adaptation to acute stress.35 However, in later stages, it suppresses inflammation by inhibiting the binding of NF-B to DNA and downregulating Cyclooxygenase-2 (COX-2) expression.36 Similarly, intracellular GSH levels typically decrease during early inflammation, which can trigger NF-B activation and promote the production of essential proinflammatory cytokines

NAD IV therapy restores cellular NAD to higher ranges, supporting energy production, cognitive function, healthy aging, and cellular repair

(2021) Vitamin B12 supplementation in diabetic neuropathy: a 1-year, randomized, double-blind, placebo-controlled trial

We also review novel findings related to the connection between the thyroid gland and gut microbiome and analyze the effects of probiotics with antioxidant properties on thyroid diseases