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Preclinical studies have shown that large doses of GLP-1RAs can reduce lipid deposition and plaque volume on the aortic surface of hyperglycemic mice via an AMPK-independent action in streptozotocin (STZ)-induced hyperglycemic and hyperlipidemic mice or type 1 diabetic rats [55]
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Can help defend cells against oxidative damage linked to accelerated aging
Conclusion GLP-1 is a powerful hormone with wide-reaching effects on metabolism, appetite, blood sugar regulation, inflammation, and potentially other systems now being studied, including the kidneys, liver, heart, brain and sleep-related breathing
