Mild side effects, such as nausea, bloating, constipation, and tiredness, can also happen at the beginning
This drug is an artificial form of the hormone glucagon-like peptide-1 secreted by the digestive system
Althumiri NA, Bindhim NF, Al-Rayes SA, Alumran A
The use the peptide Ac-Nle-c c/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH in the manufacture of a medicament for intranasal administration for use in the treatment of erectile dysfunction in a male, wherein the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH increases cGMP levels to an amount sufficient to produce an erection sufficient for sexual intercourse when the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH is administered at a sub-therapeutic dose and administered subsequent to a sub-therapeutic dose of a PDE-5 inhibitor
Tables 1 and 6) (See Supplementary Material for Clinical Takeaways)
7.2 episodes per 100 patient-years of exposure, respectively)