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In the kidney, GLP-1RAs directly induce natriuresis and diuresis by acting on the proximal convoluted tubule (PCT) through inhibition of sodium-hydrogen exchanger 3 (NHE3)
If hypoglycemia is severe or doesn't resolve with treatment, call 911 for immediate medical attention
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Antibody formation occurs in some patients, particularly with exenatide, though this rarely has clinical significance
However, either their effectiveness or their side effects at higher doses were not ideal
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