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Comparison of mechanism, pulsatility, and research applications

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A 2026 UK review of how HGF activates repair Schwann cells (Ko 2018, Scientific Reports ), the 2021 rat sciatic-nerve study where Dihexa + stem cells improved motor recovery, the VM202 / Engensis HGF gene-therapy Phase 3 in painful diabetic peripheral neuropathy (results posted Jan 2025), chemotherapy-induced neuropathy (CIPN) and the duloxetine question, and the 2026 AthiraLeonaBio pivot taking the oral HGF/MET modulator ATH-1105 into ALS with an honest account of why Dihexa still has zero human neuropathy data Read the full review Neuroscience 27 May 2026 Dihexa for Migraine & Chronic Migraine: The 2026 UK Review Rigorous 2026 UK review of Dihexa for migraine and chronic migraine

Nevertheless, various approaches that may help sustain cognitive resilience during aging are emerging

PMID: 26406389 Potga, A