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GIP receptor activation in the context of GLP-1 co-agonism appears to enhance weight loss beyond what GLP-1 activation alone achieves

Ensure you are consuming adequate protein (0.8-1 gram per pound of body weight) to support muscle preservation, even when your appetite is suppressed

This claim builds on research from Harvard published in July 2024, which found a significantly increased risk of NAION among semaglutide users, followed by additional studies in January 2025 and warnings from the Danish Medicines Agency

We met with experts at the University of California (UC) Davis, US, to discuss how researchers explore organs beyond the gut that secrete GLP-1, as the brain and pancreatic alpha cells also produce this hormone

(1) Review labels to avoid excess added sugars (1) and sugar alcohols which can cause GI distress (17), and discuss long-term use with your healthcare team

Laboratory research expanded into studies exploring its signaling behavior and interaction with cellular regulatory systems