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Target adult hemoglobin values are generally 14 to 18 grams per deciliter (g/dL) for men and 12 to 16 g/dL for women
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However, these two natural GLP-1R agonists are rapidly digested by the enzyme DPP-4 and cleared by the kidneys within 1-2 minutes, making them unsuitable for direct therapeutic use
The intranasal spray presentation enables researchers to investigate formulation stability, analytical reproducibility, peptide integrity, and standardized delivery system performance under controlled laboratory conditions
They are, however, less well tolerated than DPP-4 inhibitors, with gastro-intestinal side-effects of nausea, vomiting and diarrhoea being common following initiation (although these diminish over time in most subjects)
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