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First you observe some symptoms that clearly tell you that the therapy is going well

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Across preclinical research, BPC-157 has been reported to have a favorable tolerability profile: a 2021 Frontiers in Pharmacology review noted no reported toxicity in animal studies, with the LD1 (lethal dose for 1% of animals) not reached

Symptoms of liver toxicity include yellowing of the skin or eyes (jaundice), dark urine, persistent nausea, abdominal pain, and unusual fatigue