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Aerobic glycolysis in the retina: Functional roles of pyruvate kinase isoforms

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To further assess the role of cFLIP in TRAIL resistance, we knocked down cFLIP, which significantly induced apoptotic cell death following TRAIL treatment (Fig

doi: 10.1111/bcp.14514 70 VerdecchiaP.CavalliniC.SpanevelloA.AngeliF

Conversely, with conditions leading to neurodegeneration or chronic inflammation, oxidative stress persists long enough to lead to abnormal immune response pathwaysparticularly NF-kband prolonged treatment with GSH may lead to reduced redox tone and thus attenuating NF-kB, causing an anti-inflammatory response instead of an immuno-supportive one (Limongi et al., 2019