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Transition phase (discontinuationwashoutstabilization): strictly implement clearance times based on drug characteristicsdiscontinue semaglutide for 2 months, tirzepatide for at least 1 month (161), and long-acting formulations like exenatide for at least 3 months (153, 158, 159, 162)

Its GLP-1 activation in the brain that appears to account for the regulation of food intake, but it isnt currently clear how this might be related to GLP-1 in the blood

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A study showed that PYY null mice developed marked obesity that may be reversed by exogenous PYY treatment, suggesting that this hormone plays a role not only in postprandial early satiety but also in long-term, by regulating energy balance through unknown mechanism.27 Glucagon like peptide-1 (GLP-1) and oxyntomodulin (OXM) GLP-1 and OXM are products of the preproglucagon gene, which is expressed in the CNS, in the L-cells of the small intestine, and in pancreas

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Article References: https: ncbi.nlm.nih.gov/pmc/articles/pmc8703425/