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Full text Jamilian H, Jamilian M, Samimi M, Afshar Ebrahimi F, Rahimi M, Bahmani F, Aghababayan S, Kouhi M, Shahabbaspour S, Asemi Z
The SURPASS clinical trial program has assessed varying doses of tirzepatide across five different trials, each demonstrating significant A1c reduction and low rates of hypoglycemia compared to placebo, semaglutide (GLP-1R agonist), dulaglutide (GLP-1R agonist), and insulin (lispro, glargine, degludec)
Additionally, patients with a history of diabetic retinopathy should be monitored for worsening retinopathy, particularly with rapid improvement in glucose control
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The presence of dietary fats, particularly unsaturated fats, also triggers L-cell activation, though portion control remains important given the caloric density of fats
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The number and type of receptors a compound targets determines what it can do
