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The overflow of downstream effects erupting after the occurrence of an acute stroke include, among others, energy failure and electrochemical shifts (Dirnagl et al., 1999), metaplasticity (Murphy and Corbett, 2009), the activation of molecular, multi-omics pathways (Montaner et al., 2020), immune responses (Chamorro et al., 2012), as well as neurodegeneration (Castillo et al., 2019)

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Kinetic coupling of intercofactor electron transfer with phosphate transfer to acetyl-thiamin diphosphate via a transient FAD semiquinone/hydroxyethyl-ThDP radical pair

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