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5.4 Effects of COVID-19 and CoV-2 S on innate immunity Although viruses usually supress or avoid host immunity, CoV-2 S has been suggested to induce inflammation via a TLR2 (or TLR4) and MyD88-dependent dependent activation of the NF-B pathway in human and mouse macrophages (279), and also to trigger lung cancer progression, again via TLR2 (331)